Prima RNApols®: Optimized RNA Polymerases for Consistent, Scalable Manufacturing
Primrose Bio provides comprehensive solutions for low cost and high-quality RNA manufacturing powered by Prima RNApols®, the highest performing RNA polymerases available.
Improved Quality
Maximize yield of target mRNA and minimize undesirable side-products such as double-stranded RNA (up to 100x reduction).
Efficient
Achieve 5-10x higher yield with less DNA template required, significantly reducing production costs.
Customizable
Our panel of Prima RNApols and enzyme improvement capabilities allows us to customize solutions that meet our client's unique mRNA production needs.
Cost Reduction
Achieve high capping efficiency and better cap analog utilization, reducing mRNA manufacturing costs and enhancing quality and performance of your mRNA drug substance.
Custom RNApol Evaluation
Primrose Bio has developed a panel of over 20 different RNA polymerases. We screen this panel to identify enzymes that deliver high IVT performance using your materials and to your desired Key Performance Indicators (KPIs). These include yield, dsRNA, integrity, capping efficiency and more.
- Leverage the power of the panel
- Identify an RNApol suited for your product and process
TIMELINE
6-10 WEEKS
COST
STARTING AT $20,000
Evaluation Program Details
- 01
Screening (Weeks 1-3):
We identify 20+ enzymes tailored to your target mRNA substance and KPIs, such as yield, dsRNA content, integrity, and capping efficiency.
- 02
Process Optimization (Weeks 4-7):
We fine-tune IVT conditions and transfer optimized protocols for seamless integration into your applications.
- 03
Comprehensive Analytics (Weeks 6-8):
We perform best-in-class enzyme and mRNA analytics to ensure precision and quality.
- 04
Selection (Week 9-10):
Best-performing RNA polymerases are then shipped to you for further analysis, along with the resulting mRNA products.
Tailored RNApol Improvement
Enzymes are flexible biocatalysts that can be evolved to perform with the substrates and conditions they are required to operate in. Primrose Bio has developed an industry leading, ultra-high-throughput enzyme evolution workflow to tailor RNA polymerases for mRNA manufacturing. We improve RNApols from our panel efficiently and rapidly to meet your IVT KPIs. We support this effort with high quality enzyme and mRNA analytics from our best-in-class analytical sciences team.
RNApols for GMP Manufacturing
Primrose is fully equipped to supply custom Prima RNApols for GMP manufacturing to customers, providing industry-standard solutions for the most demanding applications.
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